There are myriad opportunities for hospitals and health systems (HHSs) to engage in data-focused collaborations with other stakeholders in the healthcare industry. These collaborations include, to an increasing extent, digital health and technology companies both big and small. As both users and contributors of data in these endeavors, and because they are often on the front line for patients who have questions about the use of their data, HHSs must navigate multi-dimensional compliance issues and other legal factors. In the fourth installment of our Focus on Innovation Centers series, Jiayan Chen and Ed Zacharias outline key considerations for HHSs as they contemplate potential data-focused collaborations and other relationships.