Recent policy changes and the prospect of new organ sources have markedly altered the landscape for organ transplantation. In particular, new allocation policies for lung and liver transplants, and advances in gene-editing technology that could potentially facilitate the animal-to-human transplant process, are affecting the organ transplant community. This Jones Day White Paper reviews these developments, with particular attention to recent legal challenges and the resulting policy changes, the potential for extended use of animal organs, and the bylaws revisions under consideration by the United Network for Organ Sharing.