On 24 April 2020 United States Trade Representative (USTR) Robert Lighthizer notified Congress that the United States-Mexico-Canada Agreement (USMCA) will enter into force 1 July 2020. As a result, the North American Free Trade Agreement (NAFTA) will no longer be in effect as of this date. U.S., Canadian, and Mexican importers and exporters should thus be aware of: (1) key implementation and compliance issues; (2) new U.S. regulatory guidance; and (3) other important changes impacting labor investigations, intellectual property protection, dispute settlement, digital trade, and USMCA’s termination.