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FDA Approval Biosimilars

Alston & Bird

Biological Products Regulation Part 5: Preparing for the FDA’s Pre-License Inspection

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Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Goodwin

Genentech/Hoffmann La-Roche and Shanghai Henlius Biotech/Organon Settle Pertuzumab BPCIA Case

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On January 30, 2026, the U.S. District Court for the District of New Jersey entered a Joint Stipulation of Dismissal resolving the pertuzumab BPCIA litigation between Genentech, Inc. and Hoffmann-La Roche Inc. (together,...more

Venable LLP

Genentech and Shanghai Henlius Biotech Settle Perjeta® Biosimilar BPCIA Litigation

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On January 30, 2026, the Court ordered Genentech / Hoffmann-La Roche and Shanghai Henlius Biotech / Organon’s stipulated dismissal of Case No. 2:25-cv-14648 (D.N.J.) due to a settlement agreement between the parties.  ...more

Venable LLP

Shanghai Henlius Biotech Announces FDA Acceptance of aBLA for Proposed Avastin® Biosimilar HLX04

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On January 13, 2026, Shanghai Henlius Biotech announced the FDA acceptance of an aBLA for HLX04, its proposed biosimilar of Genentech’s Avastin® (bevacizumab). ...more

Venable LLP

Dr. Reddy’s Files aBLA for Orencia® (abatacept) Biosimilar DRL_AB

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On January 21, 2026, as part of an earnings call, Dr. Reddy’s announced the filing of an aBLA for an intravenous (IV) formulation of DRL_AB (abatacept), a proposed biosimilar of Bristol-Myers Squibb’s Orencia® (abatacept) in...more

Alston & Bird

Biological Products Regulation Part 3: Unlocking Reference Product Exclusivity: What Sponsors Need to Know

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Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Skadden, Arps, Slate, Meagher & Flom LLP

New FDA Approach to Drug Prices Adds Uncertainty to Drug Approval Process

In the first year of the second Trump administration, we have seen the Food and Drug Administration (FDA) take an unprecedented role in drug pricing policy....more

Venable LLP

Hikma Announces U.S. Launch of Prolia® / Xgeva® Biosimilars Enoby™ / Xtrenbo™ (denosumab-qbde)

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On January 19, 2026, Hikma announced the launch of Enoby™ / Xtrenbo™ (denosumab-qbde), biosimilars of Amgen’s Prolia® / Xgeva® (denosumab), following their FDA-approval in September 2025. ...more

Rothwell, Figg, Ernst & Manbeck, P.C.

How the U.S. Compares to Europe on Biosimilar Approvals and Products In the Pipeline – Updated January 22, 2026

Many Prolia®/Xgeva® (denosumab) biosimilars approved in 2025 by FDA and EMA. FDA grants first interchangeable status for rapid acting insulin aspart, KristyTM....more

Alston & Bird

Biological Products Regulation Part 2: What Is the Regulatory Pathway for Biological Products?

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Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Venable LLP

FDA Approves Third Lucentis® (ranibizumab) Interchangeable Biosimilar: Formycon’s Nufymco™

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On December 18, 2025, the FDA approved Formycon and Zydus’s Nufymco™ (ranibizumab-leyk) as the third interchangeable biosimilar of Genentech’s Lucentis® (ranibizumab). Lucentis® biosimilars have been on the market since July...more

Venable LLP

Denosumab Biosimilar Updates: Boncresa™ / Oziltus™ Approval, AVT03 Complete Response Letter

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On December 19, 2025, the FDA approved Amneal / mAbxience’s Boncresa™ / Oziltus™ (denosumab-mobz) as the nineth biosimilars of Amgen’s Prolia® / Xgeva® (denosumab). ...more

Goodwin

FDA Approves mAbxience and Amneal’s Denosumab Biosimilars

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On December 22, 2025, the FDA approved mAbxience and Amneal’s Biologics Licensing Applications (BLAs) for BONCRESA™ (denosumab-mobz) and OZILTUS™ (denosumab-mobz), biosimilars referencing Amgen’s PROLIA® (denosumab) and...more

Goodwin

FDA Approves New Dose for Celltrion’s OMLYCLO (omalizumab-igec)

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On December 3, 2025, Celltrion announced that the FDA has approved a new dose of OMLYCLO (omalizumab-igec), the first and only biosimilar designated as interchangeable with Genentech and Novartis’s XOLAIR (omalizumab). The...more

Venable LLP

Prolia® / Xgeva® Biosimilar Updates: FDA Approves Accord’s Osvyrti® / Jubereq®, Amgen and Hikma Settle BPCIA Litigation

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On November 20, 2025, the FDA approved Accord’s Osvyrti® and Jubereq® (denosumab-desu), biosimilars of Amgen’s Prolia® / Xgeva® (denosumab). ...more

Goodwin

FDA Approves Lupin’s Pegfilgrastim Biosimilar, ARMLUPEG

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Lupin Limited announced on December 1 that it received FDA approval for its biosimilar product, ARMLUPEG (pegfilgrastim-unne).  ARMLUPEG is approved as a 6 mg/0.6 mL single-dose prefilled syringe presentation, referencing...more

Venable LLP

Sandoz Launches Tyruko® (natalizumab-sztn), First U.S. Biosimilar to Tysabri®

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On November 17, 2025, Sandoz and Polpharma announced the U.S. launch of Tyruko® (natalizumab-sztn), the first and only FDA-approved biosimilar to Biogen’s Tysabri® (natalizumab) and the first biosimilar available to treat...more

Venable LLP

FDA Approves first Perjeta® Biosimilar: Shanghai Henlius Biotech / Organon’s Poherdy®

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On November 13, 2025, the FDA approved Shanghai Henlius Biotech / Organon’s Poherdy® (pertuzumab-dpzb) as the first interchangeable biosimilar of Genentech’s Perjeta® (pertuzumab). Poherdy® is approved for all of the same...more

Goodwin

Sandoz Launches Natalizumab Biosimilar

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On November 17, 2025, Sandoz announced the launch of TYRUKO® (natalizumab-sztn) in the United States as the first and only biosimilar for the treatment of relapsing forms of multiple sclerosis. TYRUKO® was approved by FDA in...more

Goodwin

FDA Approves Accord BioPharma’s Denosumab Biosimilars

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On November 20, 2025, the FDA approved Accord BioPharma’s denosumab biosimilars OSVYRTI® (denosumab-desu) and JUBEREQ® (denosumab-desu), which reference Amgen’s PROLIA® and XGEVA®, respectively. This marks the eighth set of...more

Venable LLP

Amgen Files Three New Prolia® / Xgeva® BPCIA Litigations Against Proposed Biosimilars AVT03, MB09, and ENZ215

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On November 6, 2025, Amgen filed its eighth and ninth BPCIA lawsuits against proposed biosimilars of Prolia® / Xgeva® (denosumab), Case No. 1:25-cv-17277 (D.N.J.) against Alvotech and Dr. Reddy’s AVT03 and Case No....more

Venable LLP

Dr. Pazdur in at CDER, Leadership Developments in Key FDA Offices, and FDA Announces Reforms to Accelerate Biosimilars

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Through our Venable FDA Pulse series, we provide insight into key developments within the Food and Drug Administration (FDA or the Agency), emerging trends, enforcement activity, and other topics impacting stakeholders....more

Goodwin

New FDA Guidance Aims to Simplify the Biosimilar Approval Process

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In a new draft guidance, issued on October 29, 2025, the FDA proposed major updates to simplify biosimilarity studies and potentially reduce clinical testing for therapeutic protein products. ...more

Goodwin

FDA Approves Shanghai Henlius’s Interchangeable Pertuzumab Biosimilar

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On November 13, 2025, the FDA approved Shanghai Henlius Biologics Co. Ltd.’s POHERDY (pertuzumab-dpzb) as an interchangeable biosimilar to Genentech’s PERJETA (pertuzumab). This is the first pertuzumab biosimilar to receive...more

Alston & Bird

Comparative Efficacy Studies Are No Longer the Default Requirement for Biosimilars

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Our FDA: Drug & Device Team examines the FDA’s new draft guidance that allows biosimilar developers to rely more on analytical and pharmacokinetic data, reducing the need for costly and time-consuming comparative efficacy...more

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