News & Analysis as of

FDA Approval Clinical Trials

McCarter & English, LLP

FDA Modernizes Draft Guidance on Statistical Methods to Support Clinical Trial Data

Consistent with the Food and Drug Administration’s (FDA) commitment to streamlining the prescription drug and biologics approval processes by adopting innovative approaches to clinical trial design, the agency recently...more

ArentFox Schiff

The Eyes Have It: FDA Approves Phase 1 Clinical Trial of Life Biosciences’ Reprogramming Therapy for Vision Loss

ArentFox Schiff on

The US Food and Drug Administration (FDA) has approved a Phase 1 clinical trial from Life Biosciences that aims to help certain eye cells act younger and improve vision in glaucoma and related conditions....more

Venable LLP

Dr. Reddy’s Files aBLA for Orencia® (abatacept) Biosimilar DRL_AB

Venable LLP on

On January 21, 2026, as part of an earnings call, Dr. Reddy’s announced the filing of an aBLA for an intravenous (IV) formulation of DRL_AB (abatacept), a proposed biosimilar of Bristol-Myers Squibb’s Orencia® (abatacept) in...more

Mogin Law LLP

Court Halts Merger of Only Firms Developing Life-Saving Medical Device

Mogin Law LLP on

A federal judge has paused the merger of the only two companies developing a heart device made for high-risk patients suffering from aortic regurgitation, a potentially dangerous condition that occurs when the heart’s aortic...more

Alston & Bird

Biological Products Regulation Part 2: What Is the Regulatory Pathway for Biological Products?

Alston & Bird on

Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Vicente LLP

The Legality of Distributing and Dispensing Botanical Cannabis under Schedule III

Vicente LLP on

In this collaborative analysis, Vicente LLP and the preeminent FDA law firm Kleinfeld, Kaplan & Becker LLP examine how the potential reclassification of cannabis into Schedule III could impact its distribution and dispensing....more

Goodwin

FDA Approves BMS’s BREYANZI as First MZL CAR T Therapy

Goodwin on

On December 4, 2025, the FDA approved a new indication for Bristol Myer Squibb’s BREYANZI (lisocabtagene maraleucel) for the treatment of adults with marginal zone lymphoma (MZL) who have failed treatment with or relapsed...more

Ropes & Gray LLP

FDA Outlines “Plausible Mechanism” Approval Pathway for Personalized Therapies, But Significant Questions Remain

Ropes & Gray LLP on

FDA Commissioner Martin Makary and Center for Biologics Evaluation and Research Director Vinay Prasad recently published an article in the New England Journal of Medicine (“NEJM”) outlining the guiding principles of a new...more

Goodwin

FDA Accepts Sanofi and Regeneron’s Dupixent sBLA for Priority Review

Goodwin on

On November 11, 2025, Sanofi and Regeneron announced that the FDA accepted for priority review its supplemental biologics license application (“sBLA”) for Dupixent (dupilumab) in the treatment of adults and children aged 6...more

Womble Bond Dickinson

Actualizing Therapy from Psychedelic Compounds Requires Acknowledging the Past Pioneers as well as Encouraging Cooperation from...

Womble Bond Dickinson on

In this era of industrialized capitalism, there are serious economic incentives to promote products in nascent industries. Intellectual property and the corresponding legal framework help achieve this promotion. ...more

King & Spalding

FDA Leaders Propose New “Plausible Mechanism Pathway” for Development and Approval of Drugs and Biologics

King & Spalding on

The Food and Drug Administration (FDA) has issued a statement, published electronically in the New England Journal of Medicine (NEJM) on November 12, 2025, proposing a new process for obtaining marketing authorization for...more

Goodwin

Vera Therapeutics Submits BLA to FDA for Atacicept Fusion Protein

Goodwin on

On November 7, Vera Therapeutics announced that it submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) through the Accelerated Approval Program for atacicept for the treatment of...more

Goodwin

New FDA Guidance Aims to Simplify the Biosimilar Approval Process

Goodwin on

In a new draft guidance, issued on October 29, 2025, the FDA proposed major updates to simplify biosimilarity studies and potentially reduce clinical testing for therapeutic protein products. ...more

Hogan Lovells

FDA Announces “plausible Mechanism” Approval Pathway for Certain Personalized Therapies, With Few Details

Hogan Lovells on

Late on Wednesday, U.S. Food and Drug Administration (FDA) Commissioner Marty Makary and Center for Biologics Evaluation & Research (CBER) Director Vinay Prasad published an article in the New England Journal of Medicine...more

Foley Hoag LLP

FDA Leadership Outlines “Plausible Mechanism” Pathway for Bespoke Therapies

Foley Hoag LLP on

Key Takeaways: The US Food and Drug Administration (FDA) is proposing a new “plausible mechanism” pathway that will enable the limited approval of bespoke therapies when randomized trials are impractical....more

Jones Day

FDA Proposes to Remove Comparative Efficacy Studies to Accelerate Biosimilar Development

Jones Day on

With the aim of accelerating approval of biosimilars, the U.S. Food and Drug Administration ("FDA"), in its draft guidance "Scientific Considerations in Demonstrating Biosimilarity to a Reference Product: Updated...more

Goodwin

FDA Approves Genentech’s GAZYVA® (obinutuzumab)

Goodwin on

On October 20, 2025, the FDA approved Genentech’s GAZYVA® (obinutuzumab) as a treatment for adults with lupus nephritis (LN). Gazyva is a type II humanized anti-CD20 monoclonal antibody that works by targeting and eliminating...more

Axinn, Veltrop & Harkrider LLP

Streamlining The Studies: New FDA Draft Guidance Aims To Speed Up Biosimilar Development

On Wednesday, the FDA issued a new draft guidance proposing to reduce the need for sponsors to conduct a comparative efficacy study (CES) to demonstrate biosimilarity in an abbreviated biologics license application (aBLA). ...more

Hogan Lovells

US and EU perspectives on the evolving nature of clinical requirements for biosimilars

Hogan Lovells on

The regulatory landscape for biosimilars is undergoing significant change on both sides of the Atlantic. Recent developments signal a potential shift away from the requirement for a clinical efficacy study as an approval...more

Goodwin

FDA Approves Biocon’s Denosumab Biosimilars

Goodwin on

On September 16, 2025, the FDA approved Biocon Biologics Ltd.’s BOSAYA™ (denosumab-kyqq) and AUKELSO™ (denosumab-kyqq) as biosimilars to Amgen’s PROLIA® and XGEVA®, respectively. Both biosimilars have been approved for all...more

Wilson Sonsini Goodrich & Rosati

FDA Announces Rare Disease Evidence Principles to Accelerate Treatments for Ultra-Rare Genetic Diseases

On September 3, 2025, the FDA announced the RDEP, a new framework intended to accelerate the approval of treatments for ultra-rare genetic diseases.1 The RDEP was jointly developed by the Center for Drug Evaluation and...more

Cooley LLP

FDA’s Rare Disease Evidence Principles Process Provides Guidance for Applications Supported by a Single Pivotal Trial

Cooley LLP on

On September 3, 2025, the US Food and Drug Administration (FDA) announced a new process to support the development of drugs intended to treat rare genetic diseases. The Rare Disease Evidence Principles (RDEP) process offers...more

Hogan Lovells

New FDA approval process promotes development of rare disease gene therapies

Hogan Lovells on

The U.S. Food and Drug Administration (FDA) announced a new process called “Rare Disease Evidence Principles” (RDEP), under which eligible drugs and biologics for ultra-rare diseases caused by known genetic defects will...more

Goodwin

Bio-Thera Announces Acceptance of BLA for BAT2506 Referencing Johnson & Johnson’s SIMPONI® (Golimumab)

Goodwin on

On July 16, 2025, Bio-Thera Solutions, Ltd. (“Bio-Thera”) announced that the U.S. Food and Drug Administration (“FDA”) had accepted its Biologics License Application (“BLA”) for its golimumab biosimilar, BAT2506, referencing...more

Robins Kaplan LLP

Jazz Pharms., Inc. v. Avadel CNS Pharms., LLC

Robins Kaplan LLP on

Case Name: Jazz Pharms., Inc. v. Avadel CNS Pharms., LLC, Nos. 2024-2274, 2024-2277, 2024-2278, 2025 WL 1298920 (Fed. Cir. May 6, 2025) (Circuit Judges Lourie, Reyna, and Taranto presiding; Opinion by Lourie, J.) (Appeal from...more

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