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FDA Approval Regulatory Requirements

Axinn, Veltrop & Harkrider LLP

Oliver Twisted Again: After FDA’s Court Losses, Congress Approves FDA’s Standards on Orphan Drug Exclusivity

Last week, Congress enacted the Consolidated Appropriations Act of 2026. This legislation narrows the scope of the statutory protection for drugs for rare diseases and conditions under the Orphan Drug Act, 21 U.S. Code §...more

McGuireWoods LLP

FDA’s PreCheck Pilot Program: What Manufacturers and Investors Need to Know

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On Feb. 1, 2026, the FDA officially launched its Manufacturing PreCheck Pilot Program, which is intended to de-risk and accelerate the establishment of U.S. pharmaceutical manufacturing facilities by increasing regulatory...more

Alston & Bird

Biological Products Regulation Part 5: Preparing for the FDA’s Pre-License Inspection

Alston & Bird on

Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

ArentFox Schiff

The Eyes Have It: FDA Approves Phase 1 Clinical Trial of Life Biosciences’ Reprogramming Therapy for Vision Loss

ArentFox Schiff on

The US Food and Drug Administration (FDA) has approved a Phase 1 clinical trial from Life Biosciences that aims to help certain eye cells act younger and improve vision in glaucoma and related conditions....more

Robins Kaplan LLP

Generic Launches - Fourth Quarter 2025

Robins Kaplan LLP on

This chart tracks the date, drug, reference-listed company, applicant, and indications of publicly available drug launches resulting from Abbreviated New Drug Applications and 505(b)(2) Applications....more

Alston & Bird

Biological Products Regulation Part 3: Unlocking Reference Product Exclusivity: What Sponsors Need to Know

Alston & Bird on

Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Alston & Bird

Biological Products Regulation Part 2: What Is the Regulatory Pathway for Biological Products?

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Welcome to Alston & Bird’s introduction to biological products regulation. In this five-part intro-level series, we provide answers to a number of questions drug developers may have about the regulation and regulatory pathway...more

Kelley Drye & Warren LLP

MAHA Pushback – Court Temporarily Blocks West Virginia’s Dye Ban

Kelley Drye & Warren LLP on

In March 2025, West Virginia passed one of the most aggressive Make America Healthy Again (MAHA)-inspired statutes in the country banning a number of FDA-approved food dyes. But its future is now uncertain after a federal...more

Vicente LLP

The Legality of Distributing and Dispensing Botanical Cannabis under Schedule III

Vicente LLP on

In this collaborative analysis, Vicente LLP and the preeminent FDA law firm Kleinfeld, Kaplan & Becker LLP examine how the potential reclassification of cannabis into Schedule III could impact its distribution and dispensing....more

Jones Day

FDA Drives Digital Health Forward With Pilot Program for Chronic Condition Devices

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A new Food and Drug Administration ("FDA") pilot opens the door for digital health devices without FDA premarket authorization to be used to provide care paid under the Center for Medicare and Medicaid Innovation ("CMMI")...more

Jones Day

Commissioner's National Priority Voucher Program and Coverage Considerations

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On June 17, 2025, FDA Commissioner Marty Makary launched a new priority review pilot program intended to accelerate FDA review for drug and biologic companies supporting U.S. national interests. Specifically, the...more

Butler Snow LLP

Memento Michigan Compiled Law § 600.2946(5): An Homage to Michigan’s Former Drug Immunity Law

Butler Snow LLP on

In 1995, the Michigan Legislature enacted its Drug Immunity Law, which provided an absolute defense for pharmaceutical companies in product liability suits stemming from the safety and efficacy of their drug products, the...more

Holland & Knight LLP

FDA Proposes First New Sunscreen Ingredient in Decades

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The U.S. Food and Drug Administration (FDA) on Dec. 11, 2025, announced a proposed administrative order to add bemotrizinol as a new active ingredient to the over-the-counter (OTC) sunscreen monograph. This is the first new...more

Faegre Drinker Biddle & Reath LLP

NY Federal Court Ruling Strengthens FDA Preemption for Class III Device Manufacturers

A recent preemption decision out of the Southern District of New York offers encouraging news for medical device manufacturers. In Wieder v. Advanced Bionics LLC, 2025 WL 3237257 (S.D.N.Y. Nov. 20, 2025), the magistrate judge...more

Ropes & Gray LLP

FDA Outlines “Plausible Mechanism” Approval Pathway for Personalized Therapies, But Significant Questions Remain

Ropes & Gray LLP on

FDA Commissioner Martin Makary and Center for Biologics Evaluation and Research Director Vinay Prasad recently published an article in the New England Journal of Medicine (“NEJM”) outlining the guiding principles of a new...more

Goodwin

FDA Accepts Sanofi and Regeneron’s Dupixent sBLA for Priority Review

Goodwin on

On November 11, 2025, Sanofi and Regeneron announced that the FDA accepted for priority review its supplemental biologics license application (“sBLA”) for Dupixent (dupilumab) in the treatment of adults and children aged 6...more

King & Spalding

FDA Leaders Propose New “Plausible Mechanism Pathway” for Development and Approval of Drugs and Biologics

King & Spalding on

The Food and Drug Administration (FDA) has issued a statement, published electronically in the New England Journal of Medicine (NEJM) on November 12, 2025, proposing a new process for obtaining marketing authorization for...more

Goodwin

New FDA Guidance Aims to Simplify the Biosimilar Approval Process

Goodwin on

In a new draft guidance, issued on October 29, 2025, the FDA proposed major updates to simplify biosimilarity studies and potentially reduce clinical testing for therapeutic protein products. ...more

Hogan Lovells

FDA Announces “plausible Mechanism” Approval Pathway for Certain Personalized Therapies, With Few Details

Hogan Lovells on

Late on Wednesday, U.S. Food and Drug Administration (FDA) Commissioner Marty Makary and Center for Biologics Evaluation & Research (CBER) Director Vinay Prasad published an article in the New England Journal of Medicine...more

Foley Hoag LLP

FDA Leadership Outlines “Plausible Mechanism” Pathway for Bespoke Therapies

Foley Hoag LLP on

Key Takeaways: The US Food and Drug Administration (FDA) is proposing a new “plausible mechanism” pathway that will enable the limited approval of bespoke therapies when randomized trials are impractical....more

Wolf, Greenfield & Sacks, P.C.

Navigating Medical Device Regulation and IP Protection in the United States (Part 1 of 2)

In the United States, medical device regulation and intellectual property (IP) protection are governed by complex statutory and regulatory frameworks that are distinct from—but closely related to, and in some cases...more

Alston & Bird

Comparative Efficacy Studies Are No Longer the Default Requirement for Biosimilars

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Our FDA: Drug & Device Team examines the FDA’s new draft guidance that allows biosimilar developers to rely more on analytical and pharmacokinetic data, reducing the need for costly and time-consuming comparative efficacy...more

Polsinelli

New FDA Guidance Could Speed Biosimilar Approvals and Cut Costs

Polsinelli on

Key Takeaways: The FDA released draft guidance indicating it may approve certain biosimilars without requiring a comparative efficacy study (CES), traditionally a costly and time-intensive step....more

Jones Day

FDA Proposes to Remove Comparative Efficacy Studies to Accelerate Biosimilar Development

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With the aim of accelerating approval of biosimilars, the U.S. Food and Drug Administration ("FDA"), in its draft guidance "Scientific Considerations in Demonstrating Biosimilarity to a Reference Product: Updated...more

Goodwin

FDA Grants Interchangeability Designation to Fresenius Kabi’s and Celltrion’s Denosumab Biosimilars

Goodwin on

This week the FDA granted interchangeability status to Fresenius Kabi’s and Celltrion’s respective denosumab biosimilars.  Interchangeable biosimilars can be substituted for the reference product at the pharmacy without...more

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