The Scientific Committee on Consumer Safety (SCCS) published its final opinion on HAA299 (nano) on November 25, 2021. The European Commission (EC) asked SCCS whether HAA299 (nano) is considered safe when used as an ultraviolet (UV) filter in cosmetic products up to a maximum concentration of ten percent. According to the final opinion, SCCS considers that HAA299 (nano) as covered within the provided characteristics “is safe when used as a UV-filter in dermally-applied cosmetic products up to a maximum concentration of 10%.” The final opinion states that based on the inflammatory effects on the lung after acute inhalation exposure, SCCS has concerns regarding the repeated use of products containing HAA299 (nano) in applications that could lead to inhalation exposure and does not recommend the use of HAA299 (nano) in applications that could lead to exposure of consumers’ lungs via inhalation. SCCS based its opinion on the currently available data that show “an overall very low or lack of dermal absorption of HAA299 (nano) in human skin.” If any new evidence shows that HAA299 (nano) used as a UV filter in cosmetic products can penetrate human skin (healthy, compromised, sunburned, or damaged) to reach viable cells in higher levels than demonstrated in this submission, SCCS may consider revising the assessment.

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