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FDA Approval

Venable LLP

FDA Approves Third Lucentis® (ranibizumab) Interchangeable Biosimilar: Formycon’s Nufymco™

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On December 18, 2025, the FDA approved Formycon and Zydus’s Nufymco™ (ranibizumab-leyk) as the third interchangeable biosimilar of Genentech’s Lucentis® (ranibizumab). Lucentis® biosimilars have been on the market since July...more

Venable LLP

Denosumab Biosimilar Updates: Boncresa™ / Oziltus™ Approval, AVT03 Complete Response Letter

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On December 19, 2025, the FDA approved Amneal / mAbxience’s Boncresa™ / Oziltus™ (denosumab-mobz) as the nineth biosimilars of Amgen’s Prolia® / Xgeva® (denosumab). ...more

Kelley Drye & Warren LLP

MAHA Pushback – Court Temporarily Blocks West Virginia’s Dye Ban

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In March 2025, West Virginia passed one of the most aggressive Make America Healthy Again (MAHA)-inspired statutes in the country banning a number of FDA-approved food dyes. But its future is now uncertain after a federal...more

Goodwin

FDA Approves mAbxience and Amneal’s Denosumab Biosimilars

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On December 22, 2025, the FDA approved mAbxience and Amneal’s Biologics Licensing Applications (BLAs) for BONCRESA™ (denosumab-mobz) and OZILTUS™ (denosumab-mobz), biosimilars referencing Amgen’s PROLIA® (denosumab) and...more

Vicente LLP

The Legality of Distributing and Dispensing Botanical Cannabis under Schedule III

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In this collaborative analysis, Vicente LLP and the preeminent FDA law firm Kleinfeld, Kaplan & Becker LLP examine how the potential reclassification of cannabis into Schedule III could impact its distribution and dispensing....more

Jones Day

FDA Drives Digital Health Forward With Pilot Program for Chronic Condition Devices

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A new Food and Drug Administration ("FDA") pilot opens the door for digital health devices without FDA premarket authorization to be used to provide care paid under the Center for Medicare and Medicaid Innovation ("CMMI")...more

Goodwin

FDA Approves New Dose for Celltrion’s OMLYCLO (omalizumab-igec)

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On December 3, 2025, Celltrion announced that the FDA has approved a new dose of OMLYCLO (omalizumab-igec), the first and only biosimilar designated as interchangeable with Genentech and Novartis’s XOLAIR (omalizumab). The...more

Morris James LLP

FDA Updates Depo-Provera Label to Include Brain Tumor Risk — Key Litigation Development

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The U.S. Food and Drug Administration (FDA) has approved a significant update to the prescribing information for Depo-Provera, adding a warning about a potential association with meningiomas, a type of brain tumor. This marks...more

Jones Day

Commissioner's National Priority Voucher Program and Coverage Considerations

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On June 17, 2025, FDA Commissioner Marty Makary launched a new priority review pilot program intended to accelerate FDA review for drug and biologic companies supporting U.S. national interests. Specifically, the...more

Butler Snow LLP

Memento Michigan Compiled Law § 600.2946(5): An Homage to Michigan’s Former Drug Immunity Law

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In 1995, the Michigan Legislature enacted its Drug Immunity Law, which provided an absolute defense for pharmaceutical companies in product liability suits stemming from the safety and efficacy of their drug products, the...more

Holland & Knight LLP

FDA Proposes First New Sunscreen Ingredient in Decades

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The U.S. Food and Drug Administration (FDA) on Dec. 11, 2025, announced a proposed administrative order to add bemotrizinol as a new active ingredient to the over-the-counter (OTC) sunscreen monograph. This is the first new...more

Goodwin

FDA Approves BMS’s BREYANZI as First MZL CAR T Therapy

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On December 4, 2025, the FDA approved a new indication for Bristol Myer Squibb’s BREYANZI (lisocabtagene maraleucel) for the treatment of adults with marginal zone lymphoma (MZL) who have failed treatment with or relapsed...more

Faegre Drinker Biddle & Reath LLP

NY Federal Court Ruling Strengthens FDA Preemption for Class III Device Manufacturers

A recent preemption decision out of the Southern District of New York offers encouraging news for medical device manufacturers. In Wieder v. Advanced Bionics LLC, 2025 WL 3237257 (S.D.N.Y. Nov. 20, 2025), the magistrate judge...more

Venable LLP

Prolia® / Xgeva® Biosimilar Updates: FDA Approves Accord’s Osvyrti® / Jubereq®, Amgen and Hikma Settle BPCIA Litigation

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On November 20, 2025, the FDA approved Accord’s Osvyrti® and Jubereq® (denosumab-desu), biosimilars of Amgen’s Prolia® / Xgeva® (denosumab). ...more

Goodwin

FDA Approves Lupin’s Pegfilgrastim Biosimilar, ARMLUPEG

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Lupin Limited announced on December 1 that it received FDA approval for its biosimilar product, ARMLUPEG (pegfilgrastim-unne).  ARMLUPEG is approved as a 6 mg/0.6 mL single-dose prefilled syringe presentation, referencing...more

Venable LLP

Sandoz Launches Tyruko® (natalizumab-sztn), First U.S. Biosimilar to Tysabri®

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On November 17, 2025, Sandoz and Polpharma announced the U.S. launch of Tyruko® (natalizumab-sztn), the first and only FDA-approved biosimilar to Biogen’s Tysabri® (natalizumab) and the first biosimilar available to treat...more

Venable LLP

FDA Approves first Perjeta® Biosimilar: Shanghai Henlius Biotech / Organon’s Poherdy®

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On November 13, 2025, the FDA approved Shanghai Henlius Biotech / Organon’s Poherdy® (pertuzumab-dpzb) as the first interchangeable biosimilar of Genentech’s Perjeta® (pertuzumab). Poherdy® is approved for all of the same...more

Venable LLP

FDA Leaders Outline New “Plausible Mechanism Pathway,” the Agency’s Plans to Hire More Staff, and a Pilot Aimed at Faster Meeting...

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Through our Venable FDA Pulse series, we provide insight into key developments within the Food and Drug Administration (FDA or the Agency), emerging trends, enforcement activity, and other topics impacting stakeholders....more

Ropes & Gray LLP

FDA Outlines “Plausible Mechanism” Approval Pathway for Personalized Therapies, But Significant Questions Remain

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FDA Commissioner Martin Makary and Center for Biologics Evaluation and Research Director Vinay Prasad recently published an article in the New England Journal of Medicine (“NEJM”) outlining the guiding principles of a new...more

Goodwin

Sandoz Launches Natalizumab Biosimilar

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On November 17, 2025, Sandoz announced the launch of TYRUKO® (natalizumab-sztn) in the United States as the first and only biosimilar for the treatment of relapsing forms of multiple sclerosis. TYRUKO® was approved by FDA in...more

Goodwin

FDA Approves Accord BioPharma’s Denosumab Biosimilars

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On November 20, 2025, the FDA approved Accord BioPharma’s denosumab biosimilars OSVYRTI® (denosumab-desu) and JUBEREQ® (denosumab-desu), which reference Amgen’s PROLIA® and XGEVA®, respectively. This marks the eighth set of...more

Goodwin

FDA Accepts Sanofi and Regeneron’s Dupixent sBLA for Priority Review

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On November 11, 2025, Sanofi and Regeneron announced that the FDA accepted for priority review its supplemental biologics license application (“sBLA”) for Dupixent (dupilumab) in the treatment of adults and children aged 6...more

Womble Bond Dickinson

Actualizing Therapy from Psychedelic Compounds Requires Acknowledging the Past Pioneers as well as Encouraging Cooperation from...

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In this era of industrialized capitalism, there are serious economic incentives to promote products in nascent industries. Intellectual property and the corresponding legal framework help achieve this promotion. ...more

Venable LLP

Amgen Files Three New Prolia® / Xgeva® BPCIA Litigations Against Proposed Biosimilars AVT03, MB09, and ENZ215

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On November 6, 2025, Amgen filed its eighth and ninth BPCIA lawsuits against proposed biosimilars of Prolia® / Xgeva® (denosumab), Case No. 1:25-cv-17277 (D.N.J.) against Alvotech and Dr. Reddy’s AVT03 and Case No....more

King & Spalding

FDA Leaders Propose New “Plausible Mechanism Pathway” for Development and Approval of Drugs and Biologics

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The Food and Drug Administration (FDA) has issued a statement, published electronically in the New England Journal of Medicine (NEJM) on November 12, 2025, proposing a new process for obtaining marketing authorization for...more

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